چکیده مقاله
Background and Aim: Drug resistance in intestinal parasites poses an increasing threat to the control and treatment of parasitic diseases, especially in the children as a vulnerable population This phenomenon challenges the success of disease control programs and highlights the need for new therapeutic strategies The purpose of this systematic review was to assess the current state of treatment resistance in common intestinal parasites that affect Iranian children and to suggest innovative ways to deal with this problem Methods: A systematic study was conducted in PubMed, Scopus, Web of Science, SID, and Iran Medex databases using keywords drug resistance, intestinal parasites,” “children,” “Iran,” “mebendazole, albendazole, pyrantel pamoate, metronidazole, Giardia, Ascaris, oxyurid, Enterobius, and hookworm Articles published from 2000 to 2025 that studied drug resistance or treatment efficacy in common intestinal parasites in Iranian children were included After quality evaluation, 48 articles were chosen for the present study out of the 215 retrieved publications The information on parasite species, medications taken, drug resistance rates reported were gathered and analyzed Results: Studies showed that common intestinal parasites in Iranian children are Giardia lamblia, Ascaris lumbricoides, Enterobius vermicularis, and hookworms including Ancylostoma duodenale and Necator americanus Mebendazole and Albendazole had reduced efficacy in treating Ascaris and hookworms, and Metronidazole for Giardia Some studies have reported treatment failure rates with mebendazole for Ascaris up to 30% and metronidazole resistance in Giardia up to 20% Major challenges include the lack of a comprehensive drug resistance surveillance system, and the overdosing of medications Novel therapeutic strategies, including combination therapies and the development of new drugs, were discussed Conclusion: There is a significant concern about drug resistance in Iranian Children intestinal parasites Continuous surveillance of resistance, and implementation of strict adherence to treatment protocols, and enhancement of public awareness are crucial to solve this problem Drugs like Ivermectin particularly when used in conjunction with albendazole for certain nematodes , Nitazoxanide, and Tinidazole have become viable substitutes for Giardia in cases where the nematode is resistant to benzimidazoles albendazole and mebendazole and nitroimidazoles metronidazole
کلیدواژهها
نویسندگان
Mohammad Taghi Ahady
PhD of Medical Parasitology, Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Parend Ashoori Lati
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Aria Padash
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Maryam Sadeghi Khiavi
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Somayeh Hosseini Yousef Abad
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Sahar Jalali
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
شیوه ارجاع
Ahady, Mohammad Taghi and Ashoori Lati, Parend and Padash, Aria and Sadeghi Khiavi, Maryam and Hosseini Yousef Abad, Somayeh and Jalali, Sahar,1404,Drug Resistance in Common Intestinal Parasites of Children in Iran: Novel Therapeutic Strategies,37th International Congress on Pediatrics,Tehran
ارائهشده در
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