چکیده مقاله
Introduction: A hospital infection is an infection that occurs after the patient is admitted to the hospital 48 or 72 hours later or during a certain period 10 to 30 days after the patient's discharge 25 to 50% of surgical wound infections Drug delivery systems can transfer their medicine to the target site in different forms Staphylococcus aureus is the most dangerous positivespherical bacteria cocci often cause common staphylococcal bacteria These gramskin infections, but can also cause pneumonia, heart valve infections, and bone infections Gentamicin is an aminoglycoside antibiotic used to treat several types of bacterial infections According to the given explanations, the aim of the study is to Preparation and evaluation of the effects of drug delivery nanosystem against Staphylococcus aureu by microbroth dilution and well diffusion methods in laboratory conditions Method: Firstly, mesoporous silica nanoparticles were prepared Loading mesoporous silica nanoparticles with drugs were done and nanoparticle coating using chitosan The antibacterial activity of the studied groups against Staphylococcus aureus ATCC:23235 was performed by diffusion method and according to CLSI protocol Results: The Morphological and surface characteistics of the synthesized nanoparticles were investigated with a scanning electron microscope Loading efficiency and loading capacity of gentamicin MSN nanoparticles are 99 99±0 01 and 19 96±0 01 The size of the 100 nm particles was about 50 Conclusion: Combination therapy and efficient drug delivery systems have been developed to treat infections Formula showed more antibacterial activity compared to free forms and vancomycin These carriers can improve antimicrobial activity and also reduce the required effective concentration and induce rapid bacterial clearance
کلیدواژهها
نویسندگان
Ahmad Fatahi-Vanani
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
Pegah Khosravian
Medical Plants Research Center, Basic Health Science Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
شیوه ارجاع
Fatahi-Vanani, Ahmad and Khosravian, Pegah,1403,Preparation and evaluation of the effects of drug delivery nanosystem against Staphylococcus aureus by microbroth dilution and well diffusion methods in laboratory conditions,Third International Conference on Leading Research of Nanotechnology Students,Tehran
ارائهشده در
مجموعه مقالات سومین کنفرانس بین المللی تحقیقات پیشرو دانشجویان نانو فناوری27 شهریور 1403 · تهران