چکیده مقاله
Introduction: Intestinal parasitic infections represent a significant source of morbidity among pediatric populations in developing nations, particularly among immunocompromised individuals, where the progression of the disease often manifests in severe and occasionally life threatening forms The heterogeneous geography and socio economic factors prevalent in Iran contribute to disparate patterns of infection among children exhibiting immune deficiencies The main objective of this study was to determine the prevalence of intestinal parasitic infections among immunocompromised and healthy children under 15 years of age in Iran Methods: Following PRISMA guidelines, a systematic search was conducted across PubMed, Scopus, SID, Iran Medex, and Web of Science for research articles published from 2010 to 2025, utilizing search terms such as intestinal parasites, immunocompromised children, Iran and names of specific protozoa and helminths A total of fifty seven studies focusing on immunocompromised children and forty five studies on healthy children fulfilled the inclusion criteria and were subsequently analyzed Results: Immunocompromised pediatric populations specifically those exhibiting selective IgA deficiency, common variable immunodeficiency CVID , severe combined immunodeficiency SCID , human immunodeficiency virus/acquired immunodeficiency syndrome HIV/AIDS , nephrotic syndrome, and those undergoing organ transplantation demonstrated a significantly elevated prevalence of intestinal parasitic infections in comparison to their healthy counterparts The most frequently identified parasites included Giardia lamblia 28 45% in immunocompromised individuals versus 10 15% in healthy children , Cryptosporidium spp 18 38% versus 3 8% in general pediatric populations of Iran , Blastocystis hominis 10 20% relative to ~7% , Entamoeba histolytica 8 15% against 2 5% , and Strongyloides stercoralis 5 12% contrasted with 1% The prevalence rates were notably highest in regions such as Sistan and Baluchestan Giardia, Entamoeba , Khuzestan Giardia, Blastocystis , Fars Cryptosporidium, Strongyloides , as well as in Tehran and Isfahan, where associations with HIV/CVID related infections were observed Selective IgA deficiency was particularly correlated with increased incidences of giardiasis and cryptosporidiosis Conclusion: Immunocompromised children in Iran are at markedly increased risk for intestinal parasitic infections, shaped by both immunological and geographical determinants Strategies such as molecular based screening, parental education, improved hygiene, and early diagnosis of immune disorders are critical for reducing morbidity in this population
کلیدواژهها
نویسندگان
Mohammad Taghi Ahady
PhD of Medical Parasitology, Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Maedeh Rahimi Khademlou
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Asma Irani
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Roghayyeh Jahani Janiyar
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Bahereh Rasooli
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
Aylin Mosavi
Department of Biology, Ard C , Islamic Azad University, Ardabil, Iran
شیوه ارجاع
Ahady, Mohammad Taghi and Rahimi Khademlou, Maedeh and Irani, Asma and Jahani Janiyar, Roghayyeh and Rasooli, Bahereh and Mosavi, Aylin,1404,Intestinal Parasitic Infections among Immunocompromised and Healthy Children in Iran,37th International Congress on Pediatrics,Tehran
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