چکیده مقاله
Background: Congenital heart disease CHD , the most common congenital anomaly, affects 5 6 per 1,000 live births While only 15% of cases have known causes, maternal risk factors including diabetes, poor nutrition, and hyperhomocysteinemia are implicated Hyperhomocysteinemia, which is partly modifiable by folic acid, may disrupt fetal development through oxidative stress and gene dysregulation Vitamin E, a key antioxidant, is essential during embryogenesis; however, both deficiency and excess have been linked to an increased risk of CHD This study investigates the association between neonatal serum vitamin E levels and CHD, aiming to clarify its potential etiologic role and inform preventive or therapeutic strategies Methods: This case control study, conducted in 2021 at Ayatollah Mousavi Hospital in Zanjan, Iran, compared serum vitamin E levels in 36 neonates with congenital heart disease and 36 healthy controls Infants aged 1 28 days were included based on clinical and diagnostic criteria Frequency matching was used for gestational age and sex Vitamin E levels were measured using HPLC Data were analyzed with SPSS 26 using appropriate non parametric tests Ethical approval and parental consent were obtained by institutional guidelines Results: This study included 72 neonates 36 with CHD and 36 healthy controls , matched by gestational age median: 38 0 weeks; P = 0 134 and sex P = 0 629 No significant differences were observed between groups regarding serum vitamin E levels 7 05 vs 7 85; P = 0 477 , parental consanguinity 8 3% vs 16 7%; P = 0 478 , or maternal disease history 30 6% vs 25%; P = 0 599 These findings suggest no association between serum vitamin E levels or selected demographic variables and the presence of congenital heart disease Conclusion: This study found no significant difference in serum vitamin E levels between neonates with congenital heart disease and healthy controls The findings suggest that vitamin E deficiency is not a major contributing factor to the development of CHD in neonates Further studies are recommended to clarify the potential role of vitamin E in cardiac embryogenesis
کلیدواژهها
نویسندگان
عاطفه کریمی
فرزانه معزی هیات علمی
فرزانه معزی
هیات علمی
شیوه ارجاع
کریمی, عاطفه and معزی, فرزانه,1404,Investigating the Role of Antioxidant Status in Neonatal Congenital Heart Disease: A Comparative Analysis of Serum Vitamin E Levels,37th International Congress on Pediatrics,Tehran
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مجموعه مقالات سی و هفتمین کنگره بیماری های کودکان17 مهر 1404 · تهران