چکیده مقاله
Background and purpose: Diabetes is a key public health issue due to its expanding worldwide disease burden, which is placing unsustainable demands on people with the condition, their caregivers, health systems, and society at large This study aims to investigate the bioinformatic effects of salvia plant compounds in inhibiting alpha amylase enzyme, which is a key enzyme in diabetes, in order to take an effective step in its treatment Methods: In this study, Discovery Studio, Chimera, Hyperchem and Hdock online server software were used to investigate how the compound binds to the active site of the enzyme, draw the chemical structure of compounds, optimize energy, study docking and final analysis became Findings: The studied compounds are able to occupy the active site of the enzyme, and the binding energy level in Rosmarinic acid was 195 46, Luteolin 180 34, Genkwanin 168 28 and caffeic acid 125 57 Conclusion: Considering the relatively high effectiveness of the compounds in the bioinformatics study, the effects of these compounds can be analyzed in vitro and in vivo for additional investigations
کلیدواژهها
نویسندگان
Parisa Sepahvand
Department of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran
شیوه ارجاع
Sepahvand, Parisa,1403,Investigating The Molecular Link Of Salvia Plant Compounds On The Inhibition Of Alpha-Amylase Enzyme In The Treatment Of Diabetes,10th International Conference on Interdisciplinary Studies in Health Science, Psychology, Management and Educational Sciences
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی مطالعات میان رشته ای علوم بهداشتی، روانشناسی، مدیریت و علوم تربیتی30 مهر 1403