چکیده مقاله
Although several studies have assessed the relationships between breast cancer BC and total fat intake andfat types, relative proportions of fatty acids assessed through indices are not known to be associated with BC Several fat quality indices have been published to aid the evaluation of DFQ in relation to health consequences In 1991, Ulbricht and Southgate 15 , proposed the atherogenicity index AI and thrombogenicity index TI ,which consider the ratio of subclasses of SFAs to MUFAs and PUFAs Subsequently, in 1996, Mitchellet al introduced Cholesterol Saturated Fat Index CSI Later, in 2008, Ding et al proposed that the lipophilic index LI , might be an innovative tool for evaluating fatty acids, which could be used to determine the mean fluidityof fatty acids either consumed in the diet or present in biological samples, into an index Until now, to ourknowledge, AI, TI, LI, Σω 3/Σω 6 ratio, h/H, PSR or CSI have not been studied for the association with BC inthe Middle Eastern population This study investigates the association between dietary fat quality DFQ indices and odds of BC among women This hospital based case control study assessed 464 women with pathologically confirmed BC during the past year and 498 apparently healthy controls of similar age and residence Dietary intake was assessed using a validated food frequency questionnaire FFQ and DFQ indices were calculated by formula We calculated DFQ indices based established protocols as detailed below:Polyunsaturated fatty acids/saturated fatty acids ratio PSR =PUFAs: SFAs ratio Atherogenicity index AI = l2:0 4 x l4:0 16:0 / Σω 6 PUFA Σ ω 3 PUFA ΣMUFA ω 9 , where 12:0=lauric acid,14:0=myristic acid, 16:0=palmitic acid, Σω 6 PUFA=sum of omega 6 polyunsaturated fatty acids, Σω 3 PUFA=sum of omega 3 polyunsaturated fatty acids, and ΣMUFA ω 9=sum of omega 9 monounsaturated fatty acidsThrombogenic index TI = 14:0 16:0 18:0 / 0 5ΣMUFA 0 5Σω 6 PUFA 3 Σω 3 PUFA Σ ω 3 PUFA / Σω 6 PUFA ; where 14:0=myristic acid, 16:0=palmitic acid, 18:0=stearic acid, MUFA= monounsaturated fatty acids, Σω 6 PUFA=sum of omega 6 polyunsaturated fatty acids, Σω 3 PUFA=sum of omega 3 polyunsaturated fatty acids Σω 3 / Σω 6 ratio = where Σω 3=sum of omega 3 PUFAs, Σω 6=sum of omega 6 PUFAs Dietary lipophilic index= The lipophilic index of dietary intake was computed by multiplying the intake of each fatty acid in grams by its specific melting point °C , adding the products, and then dividing by the total of fatty acid intake in grams Dietary lipophilic index LI =Σ Fatty acid g i×Melting point °C i / ΣFatty acid g i Cholesterol/saturated fat index CSI The Cholesterol Saturated Fat Index CSI has potential as a dietary self monitoring tool and enables patients to monitor their progress toward a cholesterol lowering The likelihood of BC was evaluated across quartiles of specific DFQ indices scores atherogenicity index AI , thrombogenic index TI , hypo and hypercholesterolemic fatty acids ratio h/H , omega 3 to omega 6 polyunsaturated fatty acids ratio Σω 3/Σω 6 , polyunsaturated fatty acids/saturated fatty acids ratio PSR , dietary lipophilic index LI , Cholesterol/saturated fat index CSI
کلیدواژهها
نویسندگان
Bahareh Sasanfar
Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University ofMedical Sciences, Yazd, Iran۲Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran۳Cancer Research Cen
Maedeh Mozafarinia
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, I R Iran
Fatemeh Toorang
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, I R Iran Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University ofMedical Sciences, Tehran, Iran
Amin Salehi-Abargouei
Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University ofMedical Sciences, Yazd, Iran۲Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran Yazd Cardiovascular
Kazem Zendehdel
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, I R Iran Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran,I R Iran Breast Diseases Research Center, C
شیوه ارجاع
Sasanfar, Bahareh and Mozafarinia, Maedeh and Toorang, Fatemeh and Salehi-Abargouei, Amin and Zendehdel, Kazem,1402,Dietary Fat Quality (DFQ) Indices and Breast Cancer Risk:Report from a Large-Scale Case-Control Study,The 7th International Conference on Interdisciplinary Studies in Food Industry and Nutrition Sciences of Iran,Tehran
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