چکیده مقاله
Ochratoxin A OTA is a widespread mycotoxin In this study we examined the role of theaqueous extract of probiotic treating of the depression like behaviors and inflammationinduced by Ochratoxin using animal model of behavioral tests by 14 day treatment ofOTA in mice Markers of oxidative stress including malondialdehyde MDA , andglutathione GSH , CAT and SOD activity and as well as pro inflammatory cytokineinterleukin 6 IL 6 , TNF α, Nrf2 pathway Keap1, TLR4, and NF κB were alsoevaluated The results revealed that OTA significantly impairs depression like behaviors andinflammations Administration of OTA increased the contents of IL 6, TNF α, MDA,CAT, reduced SOD and the GSH content The probiotic 2 × 118 CFU/mL significantlyalleviated neurobehavioral impairments, oxidative damage, inflammatory cytokines BDNFand CREB protein and transcript levels compared to OTA In conclusion, it is suggested that the neuroprotective effects of probiotic might be due toantioxidant and anti inflammatory properties
کلیدواژهها
نویسندگان
Mohammad Reza Saebi
Ph D student in Food Hygiene, Faculty of Veterinary Medicine, Islamic Azad University, ShahrekordBranch, Iran
Ebrahim Rahimi
Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Shahrekord Branch,Islamic Azad University, Shahrekord, Iran
Elaheh Tajbakhsh
Department of microbiology, Faculty of Basic Silences, Islamic Azad University, Shahrekord Branch, Iran
Fahimeh Nourbakhsh
Ph D of Toxicology, Deputy of Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran
شیوه ارجاع
Saebi, Mohammad Reza and Rahimi, Ebrahim and Tajbakhsh, Elaheh and Nourbakhsh, Fahimeh,1402,Probiotics efficiently counteract inflammation and depression-like behaviors induced by Ochratoxin-A,The 7th International Conference on Interdisciplinary Studies in Food Industry and Nutrition Sciences of Iran,Tehran
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مجموعه مقالات هفتمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران30 آبان 1402 · تهران