چکیده مقاله
Ochratoxin A OTA is one of the most important secondary metabolites of Penicilliumand Aspergillus Ochratoxin was recognized in 1265 as the most important carcinogenicmycotoxin in agricultural products Due to the key role of the lungs in maintaining thefunction of other organs of the body, we examined the role of the Zataria multiflora extract ZM in an experimental model of lung inflammation induced by Ochratoxin A in mice Hence the study was designed with 14 day gavages of OTA in mice Markers of oxidativestress including, pro inflammatory cytokine interleukins, TNF α, Nrf2 pathway Keap1,TLR4, MnSOD, H0 1, Nrf2 and apoptotic factors Bax/Bcl2, Caspase 3 Caspase 2 werealso evaluated The results revealed that Nrf2 pathway and pro inflammatory cytokineinterleukins associated proteins were detected which are involved in inflammation andtissue damage Administration of Administration of Zataria multiflora 25 and 50 mg/kg significantly alleviated lung inflammation, oxidative damage, inflammatory cytokines andapoptosis protein levels compared to OTA In conclusion, the results of the study show thatZataria multiflora has strong antioxidant effects against inflammation and apoptosis ofOTA toxicity in lung tissue
کلیدواژهها
نویسندگان
Fahimeh Nourbakhsh
Ph D of Toxicology, Deputy of Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Reza Saebi
Ph D student in Food Hygiene, Faculty of Veterinary Medicine, Islamic Azad University, ShahrekordBranch, Iran
Elaheh Tajbakhsh
Department of microbiology, Faculty of Basic Silences, Islamic Azad University, Shahrekord Branch, Iran
Ebrahim Rahimi
Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Shahrekord Branch,Islamic Azad University, Shahrekord, Iran
شیوه ارجاع
Nourbakhsh, Fahimeh and Saebi, Mohammad Reza and Tajbakhsh, Elaheh and Rahimi, Ebrahim,1402,Pulmonoprotective Action of Carvacrol in anexperimental model of lung inflammation induced byOchratoxin-A,The 7th International Conference on Interdisciplinary Studies in Food Industry and Nutrition Sciences of Iran,Tehran
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مجموعه مقالات هفتمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران30 آبان 1402 · تهران