چکیده مقاله
Bone remodels via resorption and formation, two phenomena that continuously occur in bone turnover The RANKL/RANK/ OPG pathway is one of the several mechanisms that affect bone turnover The RANKL/OPG ratio has a substantial role in bone resorption An imbalance between formation and resorption is related to an increased RANKL/OPG balance OPG, a member of this system, can bind to RANKL and suppress RANK RANKL interaction, and subsequently, inhibit further osteoclastogenesis The serum levels of RANKL and OPG in the bone microenvironment are vital for osteoclasts formation The RANK/RANKL/OPG system plays a role in the pathogenesis of bone disorders This system can be considered a new treatment target for bone disorders Soy isoflavones affect the RANK/RANKL/OPG system through numerous mechanisms Soy isoflavones decrease RANKL levels and increase OPG levels Therefore, isoflavones improve bone metabolism and decrease bone resorption Soy isoflavones decrease serum markers of bone resorption and improve bone metabolism However, while the available data are promising, the results of several studies reported no change in RANKL and OPG levels with isoflavones supplementation In this regard, current evidence is insufficient for conclusive approval of the efficacy of isoflavones on RANKL/RANK/OPG and further research, including animal and human studies, are needed to confirm the effect of soy isoflavones on the RANKL/RANK/OPG pathway This study was a review of available evidence to determine the role of isoflavones in bone hemostasis and the RANK/RANKL/OPG pathway The identification of the effects of isoflavones on the RANKL/RANK/OPG pathway directs future studies and leads to the development of effective treatment strategies for bone disorders
کلیدواژهها
نویسندگان
Saeedeh Hosseini Hooshiar
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of MedicalSciences, Kashan, IR, Iran
Mohammad Tobeiha
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of MedicalSciences, Kashan, IR, Iran
Sadegh Jafarnejad
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of MedicalSciences, Kashan, IR, Iran
شیوه ارجاع
Hosseini Hooshiar, Saeedeh and Tobeiha, Mohammad and Jafarnejad, Sadegh,1402,Soy Isoflavones and Bone Health: Focus on theRANKL/RANK/OPG Pathway,The 7th International Conference on Interdisciplinary Studies in Food Industry and Nutrition Sciences of Iran,Tehran
ارائهشده در
مجموعه مقالات هفتمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران30 آبان 1402 · تهران