چکیده مقاله
Today, rapid industrialization and urbanization have led to numerous human activities that discharge variouspollutants including polycyclic aromatic hydrocarbons PAHs into the environment PAHs are mainlyderived from anthropogenic activities related to pyrolysis and incomplete combustion of organic matter Phenanthrene is the simplest non linear polycyclic aromatic hydrocarbon, which under certain conditions canlead to tumor, sensitivity allergy and autoimmunity, etc Phenanthrene occurs in fossil fuels and is presentin products of incomplete combustion Some of the known sources of phenanthrene in the atmosphere arevehicular emissions, coal and oil burning, etc Elastase is a serine protease produced by the pancreas Itsprimary role is the breakdown of elastin, a protein that imparts elasticity to connective tissue In this study,the function and stability of elastase enzyme under the influence of phenanthrene and in fact the effect of thistoxic compound on the human body is done according to the data obtained from spectroscopic methods During this investigation, the fluorescence emission of elastase was regularly increased by the inclusion ofphenanthrene As a result, it was found that phenanthrene interacts with elastase and leads to changes in theprotein microenvironment around tryptophan residues
کلیدواژهها
نویسندگان
Mahbubeh Abdellahi
Student , Department of Biology, Shahrekord University, Shahrekord, Iran
Sadegh Farhadian
Assistant Professor,Department of Biology, Shahrekord University, Shahrekord, Iran
Behzad Shareghi
Full Profesor, Department of Biology, Shahrekord University, Shahrekord, Iran
شیوه ارجاع
Abdellahi, Mahbubeh and Farhadian, Sadegh and Shareghi, Behzad,1402,Spectroscopic study of phenanthrene on the elastase structureand activity,The 7th International Conference on Interdisciplinary Studies in Food Industry and Nutrition Sciences of Iran,Tehran
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مجموعه مقالات هفتمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران30 آبان 1402 · تهران