چکیده مقاله
One of the major contributors to male infertility is azoospermia 2 Among genetic causes, Y chromosome deletions play a significant role in infertility, with a reported frequency of 10 15% in individuals with severe azoospermia and oligospermia It has been proposed that fertility related genes reside on the Y chromosome, and their absence leads to infertility, a hypothesis later termed the azoospermia factor A study investigating the effect of stem cell factor on the proliferation and differentiation of spermatogonial cells in seminiferous tubules from adult rat testes using a model of obstructive azoospermia and a tissue culture system revealed that stem cell treatment enhanced the number of spermatogonia, spermatocytes, Leydig cells, and spermatids within testicular tissue In this experimental study, 25 rats age 6 to 8 weeks after creating the azoospermia model were divided into five groups include healthy control, azoospermia, azoospermia aerobic exercise, azoospermia stem cells and azoospermia aerobic exercise stem cells The azoospermia model was injected intraperitoneally with busulfan at a dose of 40 mg per rat it is possible that the therapeutic interventions of aerobic exercise and stem cells can help to reduce infertility, however, more studies will be necessary to clarify the definitive results in this field The results of the present study showed that azoospermia caused a significant increase in the expression of the azoospermia factor gene, and the intervention of aerobic exercise and stem cells led to a decrease in the expression of the azoospermia infertility gene of the testicular tissue factor Therefore, according to the results of this research, it is possible that aerobic exercise to stem cells can help to improve infertility in Azoospermic samples
کلیدواژهها
نویسندگان
Moharm Namkil
PhD Student in Sport Physiology, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Alireza Barari
Associate Professor, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Asieh Abbasi Daloii
Associate Professor, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Parvin Farzanegi
Associate Professor, Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran
شیوه ارجاع
Namkil, Moharm and Barari, Alireza and Abbasi Daloii, Asieh and Farzanegi, Parvin,1404,Endurance Training, stem cell and laser therapy on Gene Expression of PGC, GNRH1, BTB, AZFa and CFTR in Infertile Rats,the Ninth international Conference on Sports Science, Physical Education and Social Health,Tehran
ارائهشده در
مجموعه مقالات نهمین کنفرانس بین المللی علوم ورزشی، تربیت بدنی و سلامت اجتماعی31 شهریور 1404 · تهران