چکیده مقاله
Background: Major depressive disorder MDD is a multifactorial disease that can affect patient's quality of life Low intake of nutrients and antioxidants have been proposed to be linked to depression The present study was conducted with the aim of investigating the effect of adding oral vitamin C to the standard treatment of major depressive disorder Methods: This study was a double blind randomized clinical trial that was conducted on 88 MDD patients referred to psychiatric clinics of the Yazd University of Medical Sciences Patients were randomly received vitamin C n=44 or placebo n=44 for 2 months Demographic characteristics including gender, age, marital status, level of education, occupation and duration of disease were collected The Hamilton depression questionnaire was filled for the patients at baseline, and 1 and 2 month follow ups Data analysis was performed using the SPSS version 18 software Results: Out of 88 examined patients, 41 46 6% were male and 47 53 4% were female The groups did not differ in gender p=0 285 , marital status p=0 813 , occupation p=0 875 , education level p=0 679 , age p=0 345 , and depression duration p=0 728 No significant between group difference was found in mean depression score between baseline p=0 628 and one month after treatment p= 0 534 The mean depression score was significantly higher in the placebo group compared to the vitamin C group two months after treatment p=0 030 Conclusion: Adding vitamin C to the standard treatment was effective in improving mood in MDD patients Therefore, adding vitamin C to standard MDD treatment is recommended
کلیدواژهها
نویسندگان
Reza Bidaki
Fellowship in Neuropsychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Razie Salehabadi
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Zanireh Salimi
Assistant professor of psychiatry, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
شیوه ارجاع
Bidaki, Reza and Salehabadi, Razie and Salimi, Zanireh,1404,Vitamin C as an adjuvant for treating major depressive disorder, a randomized placebo-controlled clinical trial,17th International Conference on Modern Research in Psychology, Social Sciences, Educational Sciences
ارائهشده در
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