چکیده مقاله
Background and purpose: Multiple sclerosis MS is a complex inflammatory disease in which demyelination occurs in the central nervous system affecting approximately 2 5 million people worldwide Intestinal microbiome changes play an important role in the etiology of chronic diseases This study aimed to investigate the effect of probiotic supplementation on systemic inflammation in patients with MS Materials and methods: A 12 week double blind clinical trial study was designed and seventy patients with MS were randomly divided into two groups receiving probiotics and placebo Patients in the intervention group received two capsules containing multi strain probiotics daily and patients in the control group received the same amount of placebo Factors associated with systemic inflammation were assessed at the beginning and end of the study Results: Sixty five patients were included in the final analysis There was no significant difference between the two groups in terms of baseline variables except for the duration of the disease P>0 05 At the end of the study, probiotic supplementation compared to the placebo caused a significant reduction in the serum levels of CRP 0 93± 1 62 vs 0 05 ± 1 74, P=0 03 , TNF α 2 09 ± 1 88 vs 0 48 ± 2 53, P=0 015 and IFN γ 13 18± 7 33 vs 1 93± 5 99, 29 P
کلیدواژهها
نویسندگان
Mehran Rahimlou
Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Seyed Ahmad Hosseini
Department of Nutrition, Faculty of Medicine, Zanjan University of Medical Sciences, ۵ Zanjan, Iran
Nazila Hasaniani
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of ۷ Medical Sciences, Ahvaz, Iran
شیوه ارجاع
Rahimlou, Mehran and Hosseini, Seyed Ahmad and Hasaniani, Nazila,1401,Probiotic supplementation and systemic inflammation in relapsing-remitting 1 multiple sclerosis: A randomized, double-blind, placebo-controlled trial,Sixth International Conference on Interdisciplinary Studies in Iranian Food Industry and Nutrition Sciences,Tehran
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مجموعه مقالات ششمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران28 دی 1401 · تهران