چکیده مقاله
Attention Deficit Hyperactivity Disorder ADHD is one of the most common mental disorders in children and adolescents Probiotics supplementation may help to modification of gut microbiome and consequently improve some ADHD symptoms Thus, this study aimed to assess effect of probiotic supplementation on ADHD patients aged 4 16 years In this study 60 Iranian ADHD children were randomly assigned to receive encapsulated Lactobacillus plantarum PTCC 1896™ A7 and Bifidobacterium animalis subsp Lactis BB 12® probiotic pearls or placebo for 8 weeks Assessment of ADHD symptoms was conducted using Conners' Parent Rating Scale CPRS and Integrated Visual and Auditory Continues Performance Test IVA/CPT at baseline and the end of study There was no significant difference in the CPRS total score and its subscales between two groups A significant higher score was observed in auditory response control in the probiotic group versus the placebo group at the endpoint probiotic group: 91 55 ± 16 69; placebo group: 80 55 ± 17 43; p= 0 02 Furthermore, hyperactivity/impulsivity symptoms were improved among five patients in the probiotic group p=0 06 Probiotic supplementation may have some beneficial effects on some outcomes related to ADHD such as auditory response control Improvement of hyperactivity/impulsivity symptoms in some patients in the probiotic group along with improving in auditory response control in this group may be recommended a beneficial effect of probiotic supplement on hyperactivity/impulsivity symptoms and not inattentive part in ADHD
کلیدواژهها
نویسندگان
Maryam Emadzadeh
Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra Sadat Sangsefidi
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Zohreh Sadat Sangsefidi
Department of Nutrition, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
Fatemeh Moharreri
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Azam Sadat Heydari Yazdi
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Saeid Eslami
Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
شیوه ارجاع
Emadzadeh, Maryam and Sangsefidi, Zahra Sadat and Sangsefidi, Zohreh Sadat and Moharreri, Fatemeh and Heydari Yazdi, Azam Sadat and Eslami, Saeid,1401,The effect of encapsulated probiotic on Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial,Sixth International Conference on Interdisciplinary Studies in Iranian Food Industry and Nutrition Sciences,Tehran
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