چکیده مقاله
Purpose: This Numerous clinical trials have examined the beneficial effects of vitamin D supplementation inchildren and adolescents; however, the results of these studies are inconsistent Therefore, we conducted thecurrent systematic review and meta analysis to evaluate the effect of vitamin D supplementation oninflammatory biomarkers in children and adolescents Methods: Databases including PubMed, Cochrane Library, Embase databases, Scopus, and Google Scholarwere searched by two reviewers independently up to April 2023 for RCTs investigating the effect of vitaminD supplementation on inflammatory biomarkers in children and adolescents Data were pooled usingrandom efects meta analysis and presented as standardised mean diference Hedges g with 95% confdenceintervals 95% CI Subgroup analysis was performed to investigate the efects of duration of supplementationand total dosage of vitamin D, age and weight Results: Totally, 858 participants were enrolled in our meta analysis and 5 to 18 years of age vitamin Dsupplementation wasn't associated with signifcant reductions in CRP WMD: 0 14 mg/dl, 95%CI: 0 53to0 24, P=0 465 , IL 6 WMD: 0 27, 95%CI: 0 07to0 61, P=0 125 , IL 10 WMD: 0 6, 95%CI: 0 29to0 148, P=0 186 and TNF WMD: 1 50, 95% CI: 1 58to0 56, P=0 346 Subgroup analysis based onindicated that the overweight and obesity of the participants in the intervention could explain a reason forthe heterogeneity I2=0 0%, P=0 434 ,so that, the effect of vitamin D supplementation on CRP wassignificant for studies in which participants were obese or overweight WMD: 0 62mg/dl, 95%CI: 0 76to 0 48, P
کلیدواژهها
نویسندگان
Nazgol Bahreini
Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Masoud Khorshidi
Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University ofMedical Sciences, Tehran, Iran
شیوه ارجاع
Bahreini, Nazgol and Khorshidi, Masoud,1403,Effect of vitamin D supplementation on inflammatorybiomarkers in children and adolescents: a systematic reviewand meta-analysis of randomized clinical trials,Eighth International Conference on Interdisciplinary Studies in Food industry and Nutrition Science of Iran,Tehran
ارائهشده در
مجموعه مقالات هشتمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران30 آبان 1403 · تهران