چکیده مقاله
With the spread of chronic and inflammatory diseases in today's society, MS is very significant Multiple sclerosis MS is a neurodegenerative inflammatory disease that is associated with physical, mental problems and disabilities Its prevalence is twice as common in women as men The function of neuronal myelin degradation in this disease occurs more in the cervical region of the spinal cord The advanced stages of the disease disrupt the immune system, the body's antioxidant activity and the proper functioning of nerve cells This disease causes the overexpression of immune inflammatory factors such as interleukin 6 IL 6 , decreases the amount of Hot Shock Proteins 70 HSP , Increases the activity of JAK/STAT signalling paths as well as MAPK/ERK and also the expression of Vascular Endothelial Growth Factor VEGF plays an important role in this disease For the treatment of MS, there are several chemical drugs such as Fingolimod, Glatiramer acetate, Natalizumab, which inhibit the function of inflammatory factors, angiogenesis and prevent the destruction of neurons In this study, with the aim of reducing the use of chemical drugs, reducing its side effects, as well as helping to treat this disease, aerobic exercises such as swimming in water were tested on groups of C57BL/6 mice induced by MS According to the ethical protocols performed and methods for purifying the DNA of mice, according to statistical data, it was found that aerobic exercise can inhibit the mentioned signalling JAK/STAT, MAPK/ERK pathways, the expression of inflammatory factors and the entry of immune cells into the CNS as a therapeutic supplement
کلیدواژهها
نویسندگان
Ghazale Saraee
M Sc in Sport Physiology, Department of Sports Physiology, Faculty of Sport Sciences, Islamic Azad University, Isfahan, Iran
Khosro Jalali Dehkordi
Associate professor, Department of Sports Physiology, Faculty of Sport Sciences, Islamic Azad University, Isfahan, Iran
شیوه ارجاع
Saraee, Ghazale and Jalali Dehkordi, Khosro,1405,Aerobic activity, complementary therapy for MS,Tenth international Conference on Sports Science, Physical Education and Social Health,Tehran
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی علوم ورزشی، تربیت بدنی و سلامت اجتماعی31 خرداد 1405 · تهران