چکیده مقاله
This study presents a comprehensive molecular and metabolic investigation into the neuroantioxidant compounds derived from Moringa oleifera, Zingiber officinale ginger , and Paullinia cupana guarana incorporated into advanced energy drink formulations The primary objective is to elucidate the regulatory mechanisms underlying neuroprotection and enhancement of musculoskeletal function with particular emphasis on the modulation of signaling pathways including Nrf2/Keap1 activation, NF κB inhibition, AMPK regulation, and downstream MAPK and PI3K/Akt cascades, thereby enabling dose dependent control of toxicity and elimination of adverse side effects At the molecular level, bioactive phytochemicals such as flavonoids, phenolic compounds, and saponins present in the selected plants significantly induce the nuclear translocation of the transcription factor Nrf2, which consequently upregulates antioxidant response element driven genes including heme oxygenase 1 HO 1 and NAD P H quinone oxidoreductase 1 NQO1 These contribute critically to mitigating oxidative stress in neuronal and myocyte populations Concurrent suppression of NF κB signaling attenuates pro inflammatory cytokine production, thus reducing neuroinflammation and muscular oxidative damage Metabolically, the compounds enhance cellular bioenergetics by modulating AMP activated protein kinase AMPK activity, leading to improved glucose uptake and fatty acid oxidation efficiency in muscle cells Metabolomic profiling indicates significant shifts in the balance of glycolytic and oxidative phosphorylation pathways, supporting sustained ATP production under energy demand Pharmacokinetic assessments affirm optimal bioavailability facilitated by nanotechnology based delivery systems engineered to enhance solubility and targeted biodistribution of neuroantioxidant agents, thus maximizing therapeutic efficacy while minimizing systemic exposure In vitro assays employing neuronal e g , SH SY5Y and skeletal muscle cell lines demonstrate a marked increase in cell viability, mitochondrial membrane potential stabilization, and reduced apoptosis rates upon treatment with the formulated extracts In vivo behavioral evaluations using rodent models reveal significant improvements in cognitive performance memory retention and attentional tasks and enhanced muscle endurance without manifestation of dose related neurotoxicity or cytotoxicity These findings underscore the safety profile associated with the controlled administration of these botanical neuroantioxidants Furthermore, integration of advanced nanocarrier platforms such as biodegradable polymeric nanoparticles and liposomal encapsulations ensures sustained release kinetics and protection of fragile phytochemicals from oxidative degradation during storage, addressing formulation stability challenges inherent to functional beverages This pioneering research bridges phytochemistry, molecular neuroscience, metabolic biochemistry, and nanoformulation sciences to advance the design of effective, safe energy drinks that potentiate neuronal and muscular functions The mechanistic insights provide a foundation for future clinical translation and industrial optimization of energy formulations aiming at cognitive and physical enhancement without compromising consumer safety
کلیدواژهها
نویسندگان
Behzad beizaei
Master's student in Food Industry, Islamic Azad University, Science and Research Branch
Morteza Jamshid Eini
PhD in Food Technology, Islamic Azad University, North Tehran Branch
شیوه ارجاع
beizaei, Behzad and jamshid eini, Morteza,1404,Comprehensive Molecular and Metabolic Mechanisms of Selected Neuroantioxidant Compounds from Moringa, Ginger, and Guarana in Advanced Energy Drink Formulations for Optimizing Neuronal and Muscular Function with Dose-Dependent Toxicity,Ninth International Conference on Interdisciplinary Studies in Food industry and Nutrition Science of Iran,Tehran
ارائهشده در
مجموعه مقالات نهمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران29 آبان 1404 · تهران