چکیده مقاله
Anxiety, stress, and depression constitute a significant global health burden, with projections suggesting a continued rise in prevalence and societal impact in the coming decade While conventional pharmacological and psychological interventions offer relief, their limitations, including side effects and treatment resistance, underscore of novel therapeutic avenues This comprehensive review aims to examine the direct and indirect mechanisms through which psychobiotics live microorganisms, prebiotics, or synbiotics that confer mental health benefits exert their influence on the brain gut axis to ameliorate symptoms of anxiety, stress, and depression We synthesize evidence from preclinical and clinical studies, highlighting the critical role of specific bacterial strains such as Lactobacillus helveticus R0052 , Bifidobacterium longum R0175 , Lactobacillus casei Strain Shirota , and Limosilactobacillus fermentum L18 in modulating neurotransmitter production GABA, serotonin, dopamine , reducing inflammation, and regulating the hypothalamic pituitary adrenal HPA axis Furthermore, the review discusses the indirect effects of psychobiotics through enhancement of gut barrier integrity and modulation of the overall gut microbiota composition While promising, the field faces challenges related to study heterogeneity and the need for personalized approaches This review concludes that psychobiotics, with their multifaceted actions, hold substantial promise as future interventions, either as monotherapies or adjuncts, in the management of these pervasive neuropsychiatric conditions
کلیدواژهها
نویسندگان
Kimia Ghaderi
Student of Food Hygiene, SR C , Islamic Azad University, Tehran, IRAN
Samira Fayazfar
Department of Food Hygiene, SR C , Islamic Azad University, Tehran, IRAN
Omidreza Noroozi
Student of Food Hygiene, SR C , Islamic Azad University, Tehran, IRAN
شیوه ارجاع
Ghaderi, Kimia and Fayazfar, Samira and Noroozi, Omidreza,1404,Emerging Psychobiotics: Direct and Indirect Impacts on Mental Health,Ninth International Conference on Interdisciplinary Studies in Food industry and Nutrition Science of Iran,Tehran
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