چکیده مقاله
Generating physiologically relevant human tissues in vitro requires precise control over the cellular microenvironment This study presents an advanced protocol that synergies human pluripotent stem cells hPSCs with customized bioactive hybrid scaffolds By leveraging the principles of directed differentiation and mechanical signaling as previously explored in foundational studies on ECM optimization we achieved enhanced structural maturity and functional consistency Our results, validated through single cell transcriptomics and metabolic assays, demonstrate that these engineered organoids significantly outperform standard ۳D models This work provides a scalable, high fidelity platform for drug discovery and personalized regenerative medicine
کلیدواژهها
نویسندگان
Soraya Savoj
Department of Biology, SR C , Islamic Azad University, Tehran, Iran
Hamid R Soureshjani
Department of Biology, SR C , Islamic Azad University, Tehran, Iran
Ani Boghozian
Department of Danesh Pajouh, Nobel Medical Laboratory, Isfahan, Iran
شیوه ارجاع
Savoj، Soraya و Soureshjani، Hamid R و Boghozian، Ani،1404،Comprehensive Engineering of Functional Organoids: Integrating Stem Cell Niche Optimization and Bioactive Scaffolds for Advanced Pathophysiology Modeling،ششمین کنگره جهانی یافته های نوین در سلامت، علوم بهداشتی و علوم تربیت�
ارائهشده در
مجموعه مقالات ششمین کنگره جهانی یافته های نوین در سلامت، علوم بهداشتی و علوم تربیتی5 اسفند 1404