چکیده مقاله
Constipation affects 11 38% of pregnant women, driven by hormonal changes, mechanical compression, dietary factors, and iron supplementation, leading to reduced quality of life and potential complications Current management relies on lifestyle modifications and laxatives, but concerns over long term safety in pregnancy highlight the need for alternative interventions This narrative review evaluates galacto oligosaccharides GOS , a non digestible prebiotic, as a potential therapy for alleviating gestational constipation Drawing from literature spanning 2007 2025, including randomized controlled trials, systematic reviews, and mechanistic studies, we examine GOS structure, production, mechanisms of action e g , selective fermentation promoting bifidobacteria, short chain fatty acid production, and enhanced motility , and clinical evidence In non pregnant adults, GOS 5 15 g/day modestly improves stool frequency 0 3 0 5/week , consistency, and straining, with microbiota shifts observed within 1 4 weeks Pregnancy specific data are limited but suggest safety up to 20 g/day, with no adverse maternal fetal outcomes and potential benefits to maternal infant microbiomes Comparisons with other prebiotics e g , inulin indicate GOS offers milder effects but better tolerability While promising as an adjunct to dietary fiber and hydration, gaps in large scale pregnancy trials persist Overall, GOS represents a safe, microbiota targeted approach warranting further investigation to optimize dosing and efficacy in pregnant populations
کلیدواژهها
نویسندگان
Sara Sardashti Nahi
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Arghavan Omidbakhsh
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Reyhaneh Hajimohamadi
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Sara Hatefi
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Zahra Qaredaghi
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Sina Beshkooh
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
شیوه ارجاع
Sardashti Nahi, Sara and Omidbakhsh, Arghavan and Hajimohamadi, Reyhaneh and Hatefi, Sara and Qaredaghi, Zahra and Beshkooh, Sina,1404,Galacto-Oligosaccharides (GOS) Supplementation for Alleviating Constipation in Pregnant Women,Ninth International Conference on Interdisciplinary Studies in Food industry and Nutrition Science of Iran,Tehran
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مجموعه مقالات نهمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران29 آبان 1404 · تهران