چکیده مقاله
Prediabetes affects approximately 9% of adults globally and represents a critical window for preventing progression to type 2 diabetes mellitus through dietary interventions This narrative review synthesizes current evidence on the mechanistic pathways and clinical potential of resistant starch type 3 RS3 and Lactobacillus plantarum L plantarum in postprandial glucose regulation among prediabetic individuals RS3, a retrograded starch formed through cooking and cooling processes, resists small intestinal digestion and undergoes colonic fermentation, generating short chain fatty acids that modulate gut hormone secretion, enhance insulin sensitivity, and attenuate postprandial glycemic excursions L plantarum, a well characterized probiotic strain, improves glucose homeostasis through complementary mechanisms including enhancement of intestinal barrier integrity, reduction of metabolic endotoxemia, modulation of bile acid and glucose transporter expression, and production of bioactive metabolites Clinical evidence demonstrates that RS3 supplementation ≥20 g/day reduces postprandial glucose peaks by approximately 1 0 1 5 mmol/L, while L plantarum HAC01 4×10° CFU/day for 8 weeks significantly lowers 2 hour postprandial glucose and HbA1c levels in prediabetic adults The synergistic combination of RS3 and L plantarum offers theoretical advantages through complementary metabolic pathways, with RS3 serving as a prebiotic substrate that selectively stimulates probiotic activity and enhances short chain fatty acid production However, direct human trials investigating this synbiotic combination remain lacking Practical implementation strategies include incorporating cooked and cooled starchy foods rice, potatoes, pasta, legumes and fermented plant foods or standardized probiotic supplements into culturally adapted meal plans Despite promising mechanistic and preliminary clinical evidence, substantial knowledge gaps persist regarding optimal dosing regimens, long term efficacy, inter individual response variability, and potential interactions with antidiabetic medications This review highlights the need for large scale, well controlled randomized trials specifically evaluating RS3 L plantarum synbiotic formulations in prediabetic populations to establish evidence based nutritional strategies for postprandial glucose management and diabetes prevention
کلیدواژهها
نویسندگان
Sina Beshkooh
Sara Komeili MovahedHasti Beshkooh Department of Pharmacy, Kermanshah University of Medical Science, Kermanshah, IranHedieh Molaei Department of Nutrition, SR.C, Islamic Azad University, Tehran, IranKasra Soleymani Roodbari Department of Nutrition, SR.C, Islamic Azad University, Tehran, IranSoraya Radfar Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran
Sara Komeili Movahed
Sina BeshkoohHasti Beshkooh Department of Pharmacy, Kermanshah University of Medical Science, Kermanshah, IranHedieh Molaei Department of Nutrition, SR.C, Islamic Azad University, Tehran, IranKasra Soleymani Roodbari Department of Nutrition, SR.C, Islamic Azad University, Tehran, IranSoraya Radfar Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran
Hasti Beshkooh
Department of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran
Hedieh Molaei
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Kasra Soleymani Roodbari
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
Soraya Radfar
Department of Nutrition, SR C, Islamic Azad University, Tehran, Iran
شیوه ارجاع
Beshkooh, Sina and Komeili Movahed, Sara and Beshkooh, Hasti and Molaei, Hedieh and Soleymani Roodbari, Kasra and Radfar, Soraya,1404,Resistant Starch Type 3 and Lactobacillus plantarum: Mechanisms of Action in Postprandial Glucose Control for Prediabetic Individuals,Ninth International Conference on Interdisciplinary Studies in Food industry and Nutrition Science of Iran,Tehran
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