چکیده مقاله
Nanocapsulation, a cornerstone of nanoengineering in food and nutraceutical sciences, exploits colloidal thermodynamics, quantum confinement, and interfacial rheo kinetics to fabricate core shell nanostructures 1 1000 nm that stabilize labile bioactives against physicochemical degradation These systems leverage surface to volume ratios 10 6 10 10 m 1 , zeta potentials C > 40 mV , and Derjaguin Landau Verwey Overbeek DLVO interaction potentials V_max > 25 kT to ensure colloidal stability, mitigating diffusional degradation k_deg≈ 10 5 10 3 h 1 , Ostwald ripening growth rates < 10 11 m/s , and oxidative cascades peroxide values PV < 2 0 meq/kg, anisidine values AnV < 15 Core payloads encompass hydrophobic polyphenolics logP > 4 0, K_ow≈ 10 6 10 8 , lipophilic carotenoids molar absorptivity &≈ 10 5 10 6 M 1cm 1 at 430 520 nm , polyunsaturated fatty acids PUFAs, PV < 1 8 meq/kg post encapsulation , volatile monoterpenoids vapor pressures P_v≈ 100 300 Pa at 25°C , and probiotics log CFU/g 10 0 post gastrointestinal transit Shell matrices, adhering to Generally Recognized as Safe GRAS standards, include amphiphilic proteins e g , ß lactoglobulin, pI = 4 7 5 3, Maillard glycation degrees DG = 35 60% , polyelectrolytic polysaccharides e g , chitosan, degree of deacetylation DDA > 94%, pKa=6 0 6 9 , nanostructured lipid carriers NLCs, encapsulation efficiency EE > 99%, loading capacity LC 45 70 w/w% , and hybrid dendrimers branching degree DB > 0 85 Synthesis methodologies span high pressure homogenization P_h=300 1000 MPa, polydispersity index PDI 180 h at 65°C Commercialization hurdles include nanotoxicological safety reactive oxygen species ROS rates < 10 9 mol/s/mg, IC50 > 250 µg/mL in Caco 2 and HepG2 models , regulatory dosimetry acceptable daily intake ADI 1500 kg/h, process efficiency > 92% Emerging paradigms integrate machine learning predictive accuracies >98% for EE, RMSE 70% , blockchain traceability hash rates > 10 9/s , and biorefinery derived matrices length to diameter ratio L/D > 200, yield>90% These advancements pave the way for hyperfunctionalized, nutrigenomically optimized comestibles, necessitating rigorous multiparametric validations to address consumer safety, sensory acceptance hedonic scores > 8 0/9 , and global market projections USD 750 billion by 2032, CAGR 9 8%
کلیدواژهها
نویسندگان
Behzad Beizaei
PhD student in Food Technology, Islamic Azad University, Tehran Medical Sciences Branch
Morteza Jamshid Eini
PhD in Food Technology, Islamic Azad University, North Tehran Branch
Sara Jafari Rad
PhD in Food Technology, Islamic Azad University, Varamin Branch
شیوه ارجاع
Beizaei, Behzad and Jamshid Eini, Morteza and Jafari Rad, Sara,1404,A Multidisciplinary Review of Nanocapsulation Technologies: Innovations and Challenges in Food and Nutraceutical Systems,Ninth International Conference on Interdisciplinary Studies in Food industry and Nutrition Science of Iran,Tehran
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مجموعه مقالات نهمین همایش بین المللی مطالعات میان رشته ای در صنایع غذایی و علوم تغذیه ایران29 آبان 1404 · تهران